Background: The COVID-19 pandemic has caused millions of deaths worldwide. Fortunately, multiple vaccines now exist and are readily available to the majority of people. While all the available vaccines demonstrate high efficacy rates, some reporting above 90% protection from infection, any vaccine is only effective if it is accepted. Thus, vaccine hesitancy poses a threat to the success of controlling and mitigating the pandemic. While vaccine hesitancy is multidimensional, the related psychosocial factors are arguably the most crucial to understand and address. Unfortunately, due largely to the novelty of the situation, the determinants of COVID-19 vaccine hesitancy are not well studied. Therefore, the objectives of this study are: (1) to understand the psychological and sociological factors that contribute to COVID-19 vaccine hesitancy; (2) systemically review and report the current literature on the topic of interest. \nMethods: A systematic literature review was conducted on March 14, 2021 to identify articles of interest. Search terms included those related to covid-19 and vaccine hesitancy. Multiple databases were utilized including PsycINFO, SocINDEX, MEDLINE Complete, and others. \nOriginal research studies that were relevant to the topic of interest were included in the review. The search was limited by date range, including articles published from 2019-2021. \nResults: This review followed PRISMA guidelines. Given the search terms and limitations, 122 articles were reviewed. Ultimately, 42 articles were included in the study. \nDiscussion: Gender, SES, political influence, and social media, were commonly reported social factors. Health beliefs, perceptions of COVID-19 and/or the vaccines, and trust in healthcare providers and science were commonly reported psychological factors.,Honors Thesis Advisor : Dr. Elizabeth Larsen, PhD.